Abstract
A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Azabicyclo Compounds / chemistry*
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Azabicyclo Compounds / pharmacokinetics
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Fluorine / chemistry*
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Heterocyclic Compounds, 2-Ring / chemistry*
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Heterocyclic Compounds, 2-Ring / pharmacokinetics
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Humans
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Rats
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Receptors, Dopamine D3 / antagonists & inhibitors*
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Receptors, Dopamine D3 / metabolism
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Sulfur / chemistry*
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Triazoles / chemistry*
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Triazoles / pharmacokinetics
Substances
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3-(3-((4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1-phenyl-3-azabicyclo(3.1.0)hexane
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Azabicyclo Compounds
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Heterocyclic Compounds, 2-Ring
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Receptors, Dopamine D3
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Triazoles
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Fluorine
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Sulfur